Prediction of chronic lung allograft dysfunction: a systems medicine challenge.
نویسندگان
چکیده
Affiliations: Clinique Universitaire de Pneumologie, Pôle de Cancérologie, Médecine Aiguë et Communautaire, CHU Grenoble, Inserm1055, Grenoble, Université Joseph Fourier, Grenoble, European Institute for Systems Biology and Medicine, EISBM, Lyon, Institut du Thorax, Inserm UMR1087, CNRS UMR629, Service de Pneumologie, CHU de Nantes DHU2020, Nantes, Université de Nantes, Nantes, Université Joseph Fourier, Institut Albert Bonniot, Inserm 823, CHU Grenoble, Prométhée Proteomics Platform, Grenoble, Finovatis, Lyon, Université Joseph Fourier, Inserm U823, Centre de recherche Albert Bonniot, Equipe d’Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire, Grenoble, Novadiscovery, Lyon, and European Institute for Systems Biology and Medicine, CNRS, UCBL, ENS, Université de Lyon, Lyon, France. Service de Pneumologie, Centre Hospitalier Universitaire Vaudois, Lausanne, and Université de Lausanne, Lausanne, Switzerland. GATC Biotech AG, Konstanz, and Biomax Informatics AG, Planegg, Germany. Institute of Transplantation, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK. For a full list of the the SysCLAD consortium members, see the Acknowledgements section.
منابع مشابه
Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...
متن کاملTranslational Insights on Lung Transplantation: Learning from Immunology
The introduction of ex vivo lung perfusion (EVLP) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. In addition, EVLP can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. While the Toronto team targets the attenuation of th...
متن کاملIncreased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study
Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression of TLRs in peripheral blood mononuclear cells (PBMCs) can predict the clinical outcome of kidney allografts. Methods: We obtained blood sample...
متن کاملChronic lung allograft dysfunction: evolving practice.
PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...
متن کاملRespiratory metapneumoviral infection without co-infection in association with acute and chronic lung allograft dysfunction
BACKGROUND Metapneumoviral respiratory infection is a community-acquired respiratory viral (CARV) infection. Lung transplantation recipients exposed to CARV are at risk for development of allograft rejection. The cellular and molecular pathways initiated by viral infection leading to allograft dysfunction are not completely understood. The aim of this study was to identify human metapneumoviral...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The European respiratory journal
دوره 43 3 شماره
صفحات -
تاریخ انتشار 2014